Dscam-mediated repulsion controls tiling and self-avoidance
نویسندگان
چکیده
منابع مشابه
Dscam-mediated repulsion controls tiling and self-avoidance.
Recent studies have uncovered the molecular basis of self-avoidance and tiling, two fundamental principles required for the formation of neural circuits. Both of these wiring strategies are established through homophilic repulsion between Dscam proteins expressed on opposing cell surfaces. In Drosophila, Dscam1 mediates self-avoidance, whereas Dscam2 mediates tiling. By contrast, phenotypes in ...
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2008
ISSN: 0959-4388
DOI: 10.1016/j.conb.2008.05.005